Randomised, double blind placebo controlled trial of pentoxifylline in the treatment of venous leg ulcers.

ABSTRACT:

Objective

To determine whether pentoxifylline 400 mg (Trental 400) taken orally three times daily, in addition to ambulatory compression bandages and dressings, improves the healing rate of pure venous ulcers.

Design

Randomised, double blind placebo controlled trial, parallel group study of factorial design, permitting the simultaneous evaluation of alternative pharmaceutical, bandaging, and dressings materials.

Setting

Leg ulcer clinics of a teaching and a district general hospital in southern Scotland.

Participants

200 patients with confirmed venous ulcers and in whom other major causal factors were excluded.

Interventions

Pentoxifylline 400 mg three times daily or placebo.

Main outcome measure

Complete healing (full epithelialisation) of all ul

SUBMITTER: Dale JJ 

PROVIDER: S-EPMC28239 | biostudies-literature | 1999 Oct

REPOSITORIES: biostudies-literature