Causal connectivity between the human anterior intraparietal area and premotor cortex during grasp.

ABSTRACT: The cortical visuomotor grasping circuit, comprising the anterior intraparietal area (AIP), ventral premotor (PMv), and primary motor cortex (M1) allows transformation of an object's physical properties into a suitable motor command for grasp [1-9]. However, little is known about how AIP contributes to the processing of grasp-related information conveyed through the cortical grasping circuit. We addressed this by studying the consequences of AIP "virtual lesions" on physiological interactions between PMv and M1 at rest or during preparation to grasp objects with either a precision grip or a whole-hand grasp. We used a conditioning-test transcranial magnetic stimulation (TMS) paradigm to test how PMv-M1 interactions [10-12] were modified by disrupting AIP function with theta-burst TMS (cTBS

SUBMITTER: Davare M 

PROVIDER: S-EPMC2824111 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature