Antibodies to the GABA(B) receptor in limbic encephalitis with seizures: case series and characterisation of the antigen.

ABSTRACT:

Background

Some encephalitides or seizure disorders once thought idiopathic now seem to be immune mediated. We aimed to describe the clinical features of one such disorder and to identify the autoantigen involved.

Methods

15 patients who were suspected to have paraneoplastic or immune-mediated limbic encephalitis were clinically assessed. Confocal microscopy, immunoprecipitation, and mass spectrometry were used to characterise the autoantigen. An assay of HEK293 cells transfected with rodent GABA(B1) or GABA(B2) receptor subunits was used as a serological test. 91 patients with encephalitis suspected to be paraneoplastic or immune mediated and 13 individuals with syndromes associated with antibodies to glutamic acid decarboxylase 65 were used as controls.

Findings

All

SUBMITTER: Lancaster E 

PROVIDER: S-EPMC2824142 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature