Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease.

ABSTRACT:

Background

A reduction in dietary saturated fat has generally been thought to improve cardiovascular health.

Objective

The objective of this meta-analysis was to summarize the evidence related to the association of dietary saturated fat with risk of coronary heart disease (CHD), stroke, and cardiovascular disease (CVD; CHD inclusive of stroke) in prospective epidemiologic studies.

Design

Twenty-one studies identified by searching MEDLINE and EMBASE databases and secondary referencing qualified for inclusion in this study. A random-effects model was used to derive composite relative risk estimates for CHD, stroke, and CVD.

Results

During 5-23 y of follow-up of 347,747 subjects, 11,006 developed CHD or stroke. Intake of saturated fat was not associated with an in

SUBMITTER: Siri-Tarino PW 

PROVIDER: S-EPMC2824152 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature