Isothiocyanate exposure, glutathione S-transferase polymorphisms, and colorectal cancer risk.

ABSTRACT:

Background

Isothiocyanates, compounds found primarily in cruciferous vegetables, have been shown in laboratory studies to possess anticarcinogenic activity. Glutathione S-transferases (GSTs) are involved in the metabolism and elimination of isothiocyanates; thus, genetic variations in these enzymes may affect in vivo bioavailability and the activity of isothiocyanates.

Objective

The objective was to prospectively evaluate the association between urinary isothiocyanate concentrations and colorectal cancer risk as well as the potential modifying effect of GST genotypes on the association.

Design

A nested case-control study of 322 cases and 1251 controls identified from the Shanghai Women's Health Study was conducted.

Results

Urinary isothiocyanate concentrations

SUBMITTER: Yang G 

PROVIDER: S-EPMC2824157 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature