NeuroD1 induces terminal neuronal differentiation in olfactory neurogenesis.

ABSTRACT: After their generation and specification in periventricular regions, neuronal precursors maintain an immature and migratory state until their arrival in the respective target structures. Only here are terminal differentiation and synaptic integration induced. Although the molecular control of neuronal specification has started to be elucidated, little is known about the factors that control the latest maturation steps. We aimed at identifying factors that induce terminal differentiation during postnatal and adult neurogenesis, thereby focusing on the generation of periglomerular interneurons in the olfactory bulb. We isolated neuronal precursors and mature neurons from the periglomerular neuron lineage and analyzed their gene expression by microarray. We found that expression of the bHLH t

SUBMITTER: Boutin C 

PROVIDER: S-EPMC2824315 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature