Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions.

ABSTRACT:

Background

Asthma is a heterogeneous disease that is caused by the interaction of genetic susceptibility with environmental influences. Genome-wide association studies (GWASs) represent a powerful approach to investigate the association of DNA variants with disease susceptibility. To date, few GWASs for asthma have been reported.

Objectives

A GWAS was performed on a population of patients with severe or difficult-to-treat asthma to identify genes that are involved in the pathogenesis of asthma.

Methods

A total of 292,443 single nucleotide polymorphisms (SNPs) were tested for association with asthma in 473 The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) cases and 1892 Illumina general population controls. Asthma-related quantitat

SUBMITTER: Li X 

PROVIDER: S-EPMC2824608 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature