Toll-like receptor 2 gene polymorphisms, pulmonary tuberculosis, and natural killer cell counts.

ABSTRACT:

Background

To investigate whether the toll-like receptor 2 polymorphisms could influence susceptibility to pulmonary TB, its phenotypes, and blood lymphocyte subsets.

Methods

A total of 368 subjects, including 184 patients with pulmonary TB and 184 healthy controls, were examined for TLR2 polymorphisms over locus -100 (microsatellite guanine-thymine repeats), -16934 (T>A), -15607 (A>G), -196 to -174 (insertion>deletion), and 1350 (T>C). Eighty-six TB patients were examined to determine the peripheral blood lymphocyte subpopulations.

Results

We newly identified an association between the haplotype [A-G-(insertion)-T] and susceptibility to pulmonary TB (p = 0.006, false discovery rate q = 0.072). TB patients with systemic symptoms had a lower -196 to -174 deletion/delet

SUBMITTER: Chen YC 

PROVIDER: S-EPMC2824655 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature