Periostin shows increased evolutionary plasticity in its alternatively spliced region.

ABSTRACT:

Background

Periostin (POSTN) is a secreted extracellular matrix protein of poorly defined function that has been related to bone and heart development as well as to cancer. In human and mouse, it is known to undergo alternative splicing in its C-terminal region, which is devoid of known protein domains. Differential expression of periostin, sometimes of specific splicing isoforms, is observed in a broad range of human cancers, including breast, pancreatic, and colon cancer. Here, we combine genomic and transcriptomic sequence data from vertebrate organisms to study the evolution of periostin and particularly of its C-terminal region.

Results

We found that the C-terminal part of periostin is markedly more variable among vertebrates than the rest of periostin in terms of exon

SUBMITTER: Hoersch S 

PROVIDER: S-EPMC2824660 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature