Transcriptomic profiling of bovine IVF embryos revealed candidate genes and pathways involved in early embryonic development.

ABSTRACT:

Background

Early embryonic loss is a large contributor to infertility in cattle. Although genetic factors are known to affect early embryonic development, the discovery of such factors has been a serious challenge. The objective of this study was to identify genes differentially expressed between blastocysts and degenerative embryos at early stages of development.

Results

Using microarrays, genome-wide RNA expression was profiled and compared for in vitro fertilization (IVF) - derived blastocysts and embryos undergoing degenerative development up to the same time point. Surprisingly similar transcriptomic profiles were found in degenerative embryos and blastocysts. Nonetheless, we identified 67 transcripts that significantly differed between these two groups of embryos at a

SUBMITTER: Huang W 

PROVIDER: S-EPMC2824717 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature