New insights into two distinct nucleosome distributions: comparison of cross-platform positioning datasets in the yeast genome.

ABSTRACT:

Background

Recently, a number of high-resolution genome-wide maps of nucleosome locations in S. cerevisiae have been derived experimentally. However, nucleosome positions are determined in vivo by the combined effects of numerous factors. Consequently, nucleosomes are not simple static units, which may explain the discrepancies in reported nucleosome positions as measured by different experiments. In order to more accurately depict the genome-wide nucleosome distribution, we integrated multiple nucleosomal positioning datasets using a multi-angle analysis strategy.

Results

To evaluate the contribution of chromatin structure to transcription, we used the vast amount of available nucleosome analyzed data. Analysis of this data allowed for the comprehensive identification of th

SUBMITTER: Feng J 

PROVIDER: S-EPMC2824721 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature