Developmental cues and persistent neurogenic potential within an in vitro neural niche.

ABSTRACT:

Background

Neurogenesis, the production of neural cell-types from neural stem cells (NSCs), occurs during development as well as within select regions of the adult brain. NSCs in the adult subependymal zone (SEZ) exist in a well-categorized niche microenvironment established by surrounding cells and their molecular products. The components of this niche maintain the NSCs and their definitive properties, including the ability to self-renew and multipotency (neuronal and glial differentiation).

Results

We describe a model in vitro NSC niche, derived from embryonic stem cells, that produces many of the cells and products of the developing subventricular zone (SVZ) and adult SEZ NSC niche. We demonstrate a possible role for apoptosis and for components of the extracellular matri

SUBMITTER: Pierret C 

PROVIDER: S-EPMC2824744 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature