Sceptrin, a marine natural compound, inhibits cell motility in a variety of cancer cell lines.

ABSTRACT: Sceptrin, a natural compound produced by various marine sponges, was tested for its effect on cell motility. We report for the first time that sceptrin inhibits cell motility in several cancer cell lines. The compound shows no toxicity at concentrations that are double the amount of sceptrin required for maximal inhibitory effect. Both random and factor-induced migration were impaired, suggesting that sceptrin targets a central process of cell motility machinery. Activity of de novo synthesized sceptrin was indistinguishable from sceptrin purified from Agelas nakamurai, and the inhibitory activity was found to be, at least partially, due to sceptrin's capability to inhibit cell contractility. Additionally, sceptrin was found to bind to monomeric actin, further suggesting a mechanism involv

SUBMITTER: Cipres A 

PROVIDER: S-EPMC2825093 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature