Gabapentin for smoking cessation.

ABSTRACT:

Introduction

We conducted a preliminary proof-of-concept study evaluating gabapentin for the treatment of tobacco dependence.

Methods

Subjects (N = 80) were randomized to gabapentin (600 mg three times per day or 900 mg three times per day) or placebo. After a 2-week dose titration, the target dose was maintained for 9 weeks and then tapered over 1 week. Follow-up was for 12 weeks after the medication phase.

Results

The study had high dropout rates with more than one half of participants in each arm discontinuing study. Gabapentin-treated participants exhibited lower abstinence rates than placebo-treated participants; however, this difference was not significant. Smoking reduction was observed across all treatment arms compared with baseline (p < .01) but did not diff

SUBMITTER: Sood A 

PROVIDER: S-EPMC2825098 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature