The G-protein beta3 subunit 825 TT genotype is associated with epigastric pain syndrome-like dyspepsia.

ABSTRACT:

Background

Although familial clustering of functional dyspepsia (FD) has been reported, the role of genetics in the susceptibility to FD is still not well understood. Several reports indicate an association between FD and G-protein beta3 (GNB3) subunit gene polymorphism (C825T); however, these studies had small sample sizes and the findings are inconclusive. In the present study we clarified the association between GNB3 gene polymorphism and dyspepsia in a large population of Japanese subjects who visited a hospital for annual health check-up.

Methods

Subjects with significant upper gastrointestinal findings were excluded. Subjects with dyspeptic symptoms were divided into either a postprandial distress syndrome (PDS) group or an epigastric pain syndrome (EPS) group accordin

SUBMITTER: Oshima T 

PROVIDER: S-EPMC2825227 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature