Mesoscopic organization reveals the constraints governing Caenorhabditis elegans nervous system.

ABSTRACT: One of the biggest challenges in biology is to understand how activity at the cellular level of neurons, as a result of their mutual interactions, leads to the observed behavior of an organism responding to a variety of environmental stimuli. Investigating the intermediate or mesoscopic level of organization in the nervous system is a vital step towards understanding how the integration of micro-level dynamics results in macro-level functioning. The coordination of many different co-occurring processes at this level underlies the command and control of overall network activity. In this paper, we have considered the somatic nervous system of the nematode Caenorhabditis elegans, for which the entire neuronal connectivity diagram is known. We focus on the organization of the system into modul

SUBMITTER: Pan RK 

PROVIDER: S-EPMC2825259 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature