Transforming growth factor-beta-activated kinase 1 is an essential regulator of myogenic differentiation.

ABSTRACT: Satellite cells/myoblasts account for the majority of muscle regenerative potential in response to injury and muscular adaptation to exercise. Although the ability to influence this process would provide valuable benefits for treating a variety of patients suffering from muscle loss, the regulatory mechanisms of myogenesis are not completely understood. We have tested the hypothesis that transforming growth factor-beta-activated kinase 1 (TAK1) is an important regulator of skeletal muscle formation. TAK1 is expressed in proliferating C2C12 myoblasts, and its levels are reduced upon differentiation of myoblasts into myotubes. In vivo, TAK1 is predominantly expressed in developing skeletal muscle of young mice. However, the expression of TAK1 was significantly up-regulated in regenerating sk

SUBMITTER: Bhatnagar S 

PROVIDER: S-EPMC2825435 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature