"Color Timer" mice: visualization of neuronal differentiation with fluorescent proteins.

ABSTRACT: The molecular mechanisms governing the differentiation of neural stem cells (NSCs) into neuronal progenitor cells and finally into neurons are gradually being revealed. The lack of convenient means for real-time determination of the stages of differentiation of individual neural cells, however, has been hindering progress in elucidating the mechanisms. In order to be able to easily identify the stages of differentiation of neural cells, we have been attempting to establish a mouse system that would allow progression of neuronal differentiation to be visualized based on transitions between fluorescence colors by using a combination of mouse genetics and the ever-expanding repertoire of fluorescent proteins. In this study we report the initial version of such a mouse system, which we call "C

SUBMITTER: Kanki H 

PROVIDER: S-EPMC2825511 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature