Differential genomic responses in old vs. young humans despite similar levels of modest muscle damage after resistance loading.

ABSTRACT: Across numerous model systems, aging skeletal muscle demonstrates an impaired regenerative response when exposed to the same stimulus as young muscle. To better understand the impact of aging in a human model, we compared changes to the skeletal muscle transcriptome induced by unaccustomed high-intensity resistance loading (RL) sufficient to cause moderate muscle damage in young (37 yr) vs. older (73 yr) adults. Serum creatine kinase was elevated 46% 24 h after RL in all subjects with no age differences, indicating similar degrees of myofiber membrane wounding by age. Despite this similarity, from genomic microarrays 318 unique transcripts were differentially expressed after RL in old vs. only 87 in young subjects. Follow-up pathways analysis and functional annotation revealed among old su

SUBMITTER: Thalacker-Mercer AE 

PROVIDER: S-EPMC2825766 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature