Regulatory role of the MisR/S two-component system in hemoglobin utilization in Neisseria meningitidis.

ABSTRACT: Outer membrane iron receptors are some of the major surface entities that are critical for meningococcal pathogenesis. The gene encoding the meningococcal hemoglobin receptor, HmbR, is both independently transcribed and transcriptionally linked to the upstream gene hemO, which encodes a heme oxygenase. The MisR/S two-component system was previously determined to regulate hmbR transcription, and its hemO and hmbR regulatory mechanisms were characterized further here. The expression of hemO and hmbR was downregulated in misR/S mutants under both iron-replete and iron-restricted conditions, and the downregulation could be reversed by complementation. No significant changes in expression of other iron receptors were detected, suggesting that the MisR/S system specifically regulates hmbR. When

SUBMITTER: Zhao S 

PROVIDER: S-EPMC2825934 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature