Mucin AgC10 from Trypanosoma cruzi Interferes with L-selectin-mediated monocyte adhesion.

ABSTRACT: The protozoan parasite Trypanosoma cruzi has evolved sophisticated systems to evade the immune response. An important requirement for a productive immune response is recruitment of the appropriate immune cells from the bloodstream to the sites of infection. Here, we show that a mucin expressed and secreted by the metacyclic infective form of T. cruzi, AgC10, is able to interfere with L-selectin-mediated monocyte adhesion. Thus, incubation of U937 monocytic cells stably expressing L-selectin (U937LAM) with AgC10 strongly reduced their adhesion on P-selectin under flow, which is dependent on L-selectin. This treatment also results in a significant inhibition by AgC10 of U937LAM and human primary monocyte adhesion to activated vascular endothelium. This effect was specific for L-selectin, bec

SUBMITTER: Alcaide P 

PROVIDER: S-EPMC2825940 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature