Serotype-specific structural differences in the protease-cofactor complexes of the dengue virus family.

ABSTRACT: With an estimated 40% of the world population at risk, dengue poses a significant threat to human health, especially in tropical and subtropical regions. Preventative and curative efforts, such as vaccine development and drug discovery, face additional challenges due to the occurrence of four antigenically distinct serotypes of the causative dengue virus (DEN1 to -4). Complex immune responses resulting from repeat assaults by the different serotypes necessitate simultaneous targeting of all forms of the virus. One of the promising targets for drug development is the highly conserved two-component viral protease NS2B-NS3, which plays an essential role in viral replication by processing the viral precursor polyprotein into functional proteins. In this paper, we report the 2.1-A crystal struc

SUBMITTER: Chandramouli S 

PROVIDER: S-EPMC2826037 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature