Perturbations in cytokine gene expression after inoculation of C57BL/6 mice with Pasteurella pneumotropica.

ABSTRACT: Pasteurella pneumotropica can cause inflammation and abscess formation in a variety of tissues. Most commonly, P. pneumotropica produces clinical disease in immunodeficient mice or those concurrently infected with other pathogens. Because clinical disease is infrequent in immunocompetent mice harboring P. pneumotropica, some scientists consider it an opportunistic pathogen with little clinical relevance to biomedical research. However, other infectious agents, including mouse parvoviruses, mouse rotavirus, and Helicobacter spp. alter physiologic or biologic responses without causing clinical signs of illness. We investigated the potential for P. pneumotropica to modulate the transcription of cytokine genes in immunocompetent mice. In C57BL/6 mice inoculated oronasally with a minimal coloni

SUBMITTER: Patten CC 

PROVIDER: S-EPMC2826080 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature