Growth factor receptor-bound protein-7 (Grb7) as a prognostic marker and therapeutic target in breast cancer.

ABSTRACT:

Background

Growth factor receptor-bound protein-7 (Grb7) is an adapter-type signaling protein recruited to various tyrosine kinases, including HER2/neu. Grb7-specific inhibitors are in early development. As with other targeted therapies, response to therapy might be associated with target expression.

Materials and methods

Tissue microarrays containing 638 primary breast cancer specimens with 15-year patient follow-up were employed to assess Grb7 expression using our Automated QUantitative Analysis method; cytokeratin defines pixels as breast cancer (tumor mask) within the histospot, and Grb7 expression within the mask is measured with Cy5-conjugated antibodies.

Results

High Grb7 expression was strongly associated with decreased survival in the entire cohort and in the

SUBMITTER: Nadler Y 

PROVIDER: S-EPMC2826097 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature