Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set.

ABSTRACT: Alzheimer's Disease (AD) is the most widespread form of dementia during the later stages of life. If improved therapeutics are not developed, the prevalence of AD will drastically increase in the coming years as the world's population ages. By identifying differences in neuronal gene expression profiles between healthy elderly persons and individuals diagnosed with AD, we may be able to better understand the molecular mechanisms that drive AD pathogenesis, including the formation of amyloid plaques and neurofibrillary tangles. In this study, we expression profiled histopathologically normal cortical neurons collected with laser capture microdissection (LCM) from six anatomically and functionally discrete postmortem brain regions in 34 AD-afflicted individuals, using Affymetrix Human Genome

SUBMITTER: Liang WS 

PROVIDER: S-EPMC2826117 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature