MELD score is an important predictor of pretransplantation mortality in HIV-infected liver transplant candidates.

ABSTRACT:

Background & aims

Human immunodeficiency virus (HIV) infection accelerates liver disease progression in patients with hepatitis C virus (HCV) and could shorten survival of those awaiting liver transplants. The Model for End-Stage Liver Disease (MELD) score predicts mortality in HIV-negative transplant candidates, but its reliability has not been established in HIV-positive candidates.

Methods

We evaluated predictors of pretransplantation mortality in HIV-positive liver transplant candidates enrolled in the Solid Organ Transplantation in HIV: Multi-Site Study (HIVTR) matched 1:5 by age, sex, race, and HCV infection with HIV-negative controls from the United Network for Organ Sharing.

Results

Of 167 HIVTR candidates, 24 died (14.4%); this mortality rate was similar to t

SUBMITTER: Subramanian A 

PROVIDER: S-EPMC2826170 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature