Contributions of ion channel currents to ventricular action potential changes and induction of early afterdepolarizations during acute hypoxia.

ABSTRACT:

Rationale

Variability in delivery of oxygen can lead to electric instability in the myocardium and the generation of arrhythmias. In addition ischemic heart disease and angina are associated with an increase in circulating catecholamines that further increases the risk of developing ventricular tachyarrhythmias.

Objective

We investigated the net effects of acute hypoxia and catecholamines on the cardiac action potential.

Methods and results

We incorporated all published data on the effects of hypoxia on the late Na(+) current (I(Na-L)), the fast Na(+) current (I(Na)), the basal L-type Ca(2+) channel current (I(Ca-L)), and the slow (I(Ks)) and rapid components of the delayed rectifier K(+)-current (I(Kr)) in the absence and presence of beta-adrenergic receptor (beta-AR

SUBMITTER: Gaur N 

PROVIDER: S-EPMC2826175 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature