Estrogen receptor genotype and risk of cognitive impairment in elders: findings from the Health ABC study.

ABSTRACT:

Objective

To determine whether variants in the estrogen receptors 1 (alpha) and 2 (beta) (ESR1 and ESR2) genes are associated with cognitive impairment in non-demented elderly men and women.

Background

Several single nucleotide polymorphisms (SNPs) on ESR1 and ESR2 genes have been associated with a range of hormone sensitive diseases such as breast cancer and osteoporosis. Genetic variations in ESR may also influence cognitive aging but are less studied, especially among men.

Methods

We studied 2527 participants enrolled in an ongoing prospective study of community-dwelling elders. Four SNPs from ESR1 and four from ESR2 were analyzed. We measured cognitive function with the Modified Mini-Mental Status Examination (3MS) at baseline and biannually; cognitive impairment

SUBMITTER: Yaffe K 

PROVIDER: S-EPMC2826192 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature