Assessing functional annotation transfers with inter-species conserved coexpression: application to Plasmodium falciparum.

ABSTRACT:

Background

Plasmodium falciparum is the main causative agent of malaria. Of the 5 484 predicted genes of P. falciparum, about 57% do not have sufficient sequence similarity to characterized genes in other species to warrant functional assignments. Non-homology methods are thus needed to obtain functional clues for these uncharacterized genes. Gene expression data have been widely used in the recent years to help functional annotation in an intra-species way via the so-called Guilt By Association (GBA) principle.

Results

We propose a new method that uses gene expression data to assess inter-species annotation transfers. Our approach starts from a set of likely orthologs between a reference species (here S. cerevisiae and D. melanogaster) and a query species (P. falciparum). I

SUBMITTER: Brehelin L 

PROVIDER: S-EPMC2826313 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature