Evolution and diversity of secretome genes in the apicomplexan parasite Theileria annulata.

ABSTRACT:

Background

Little is known about how apicomplexan parasites have evolved to infect different host species and cell types. Theileria annulata and Theileria parva invade and transform bovine leukocytes but each species favours a different host cell lineage. Parasite-encoded proteins secreted from the intracellular macroschizont stage within the leukocyte represent a critical interface between host and pathogen systems. Genome sequencing has revealed that several Theileria-specific gene families encoding secreted proteins are positively selected at the inter-species level, indicating diversification between the species. We extend this analysis to the intra-species level, focusing on allelic diversity of two major secretome families. These families represent a well-characterised group

SUBMITTER: Weir W 

PROVIDER: S-EPMC2826314 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature