Polymorphisms of TCF7L2 and HHEX genes in Chinese women with polycystic ovary syndrome.

ABSTRACT:

Purpose

This study was to evaluate whether polymorphisms of TCF7L2 (rs7903146) and HHEX (rs1111875) genes responsible for insulin secretion are associated with the polycystic ovary syndrome (PCOS) in Chinese people.

Methods

326 PCOS patients and 290 healthy individuals as controls were studied. Blood samples were obtained for DNA analyses and hormone measurements. Genotyping of the TCF7L2 (rs7903146) and HHEX (rs1111875) genes was carried out by the polymerase chain reaction-restriction fragment length polymorphism method.

Results

We did not find statistically significant differences in the distribution of the TCF7L2 rs7903146 and HHEX rs1111875 polymorphisms between the Chinese women with PCOS and the controls. Levels of hormones such as insulin, FSH, LH, LH/FSH, P,

SUBMITTER: Xu P 

PROVIDER: S-EPMC2826618 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature