Twice daily versus four times daily insulin dose regimens for diabetes in pregnancy: randomised controlled trial.

ABSTRACT: OBJECTIVE:To compare perinatal outcome and glycaemic control in two groups of pregnant diabetic patients receiving two insulin regimens. DESIGN:Randomised controlled open label study. SETTING:University affiliated hospital, Israel. PARTICIPANTS:138 patients with gestational diabetes mellitus and 58 patients with pregestational diabetes mellitus received insulin four times daily, and 136 patients with gestational diabetes and 60 patients with pregestational diabetes received insulin twice daily. INTERVENTION:Three doses of regular insulin before meals and an intermediate insulin dose before bedtime (four times daily regimen), and a combination of regular and intermediate insulin in the morning and evening (twice daily regimen). MAIN OUTCOME MEASURES:Maternal glycaemic control and perinatal

SUBMITTER: Nachum Z 

PROVIDER: S-EPMC28269 | biostudies-literature | 1999 Nov

REPOSITORIES: biostudies-literature