Nutritional control of gene expression in Drosophila larvae via TOR, Myc and a novel cis-regulatory element.

ABSTRACT:

Background

Nutrient availability is a key determinant of eukaryotic cell growth. In unicellular organisms many signaling and transcriptional networks link nutrient availability to the expression of metabolic genes required for growth. However, less is known about the corresponding mechanisms that operate in metazoans. We used gene expression profiling to explore this issue in developing Drosophila larvae.

Results

We found that starvation for dietary amino acids (AA's) leads to dynamic changes in transcript levels of many metabolic genes. The conserved insulin/PI3K and TOR signaling pathways mediate nutrition-dependent growth in Drosophila and other animals. We found that many AA starvation-responsive transcripts were also altered in TOR mutants. In contrast, although PI3K ov

SUBMITTER: Li L 

PROVIDER: S-EPMC2827378 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature