Insulin signaling promotes germline proliferation in C. elegans.

ABSTRACT: Cell proliferation must be coordinated with cell fate specification during development, yet interactions among pathways that control these two critical aspects of development are not well understood. The coordination of cell fate specification and proliferation is particularly crucial during early germline development, when it impacts the establishment of stem/progenitor cell populations and ultimately the production of gametes. In C. elegans, insulin/IGF-like receptor (IIR) signaling has been implicated in fertility, but the basis for the fertility defect had not been previously characterized. We found that IIR signaling is required for robust larval germline proliferation, separate from its well-characterized role in preventing dauer entry. IIR signaling stimulates the larval germline ce

SUBMITTER: Michaelson D 

PROVIDER: S-EPMC2827619 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature