Identification of the polymorphisms in IFITM3 gene and their association in a Korean population with ulcerative colitis.

ABSTRACT: Interferons play critical roles in tumor pathogenesis by controlling apoptosis and through cellular anti-proliferative and differentiation activities. Interferon inducible transmembrane protein (IFITM) family genes have been implicated in several cellular processes such as the homotypic cell adhesion functions of IFN and cellular anti-proliferative activities. Expression levels of IFITM genes have been found to be up-regulated in gastric cancer cells and colorectal tumors. IFITM3 (also known as 1-8U) is a member of the IFITM family, and has been described as a key player in specification of germ cell fate. IFITM3 was first isolated from a genetic screen aimed at identifying genes involved in acquisition of germ cell competence. It has been proposed that epiblast cells have the highest expr

SUBMITTER: Seo GS 

PROVIDER: S-EPMC2827834 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature