Identification of S100A8-correlated genes for prediction of disease progression in non-muscle invasive bladder cancer.

ABSTRACT:

Background

S100 calcium binding protein A8 (S100A8) has been implicated as a prognostic indicator in several types of cancer. However, previous studies are limited in their ability to predict the clinical behavior of the cancer. Here, we sought to identify a molecular signature based on S100A8 expression and to assess its usefulness as a prognostic indicator of disease progression in non-muscle invasive bladder cancer (NMIBC).

Methods

We used 103 primary NMIBC specimens for microarray gene expression profiling. The median follow-up period for all patients was 57.6 months (range: 3.2 to 137.0 months). Various statistical methods, including the leave-one-out cross validation method, were applied to identify a gene expression signature able to predict the likelihood of progress

SUBMITTER: Kim SK 

PROVIDER: S-EPMC2828413 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature