Intracarotid administration of human bone marrow mononuclear cells in rat photothrombotic ischemia.

ABSTRACT:

Background

Increasing evidence suggests that cell therapy improves functional recovery in experimental models of stroke and myocardial infarction. So far only small pilot trials tested the effects of cell therapy in stroke patients, whereas large clinical trials were conducted in patients with ischemic heart disease. To investigate the therapeutic benefit of cell therapy to improve the recovery after stroke, we determined the efficacy of bone marrow derived mononuclear cells, which were shown to improve the recovery in experimental and clinical acute myocardial infarction studies, in a rat stroke model.

Methods

Adult male Wistar rats were randomly assigned to receive either five million human bone marrow mononuclear cells (hBMC) or placebo intraarterially 3 days after photot

SUBMITTER: Minnerup J 

PROVIDER: S-EPMC2828442 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature