Variants in FAM13A are associated with chronic obstructive pulmonary disease.

ABSTRACT: We performed a genome-wide association study for chronic obstructive pulmonary disease (COPD) in three population cohorts, including 2,940 cases and 1,380 controls who were current or former smokers with normal lung function. We identified a new susceptibility locus at 4q22.1 in FAM13A and replicated this association in one case-control group (n = 1,006) and two family-based cohorts (n = 3,808) (rs7671167, combined P = 1.2 x 10(-11), combined odds ratio in case-control studies 0.76, 95% confidence interval 0.69-0.83).

SUBMITTER: Cho MH 

PROVIDER: S-EPMC2828499 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature