Metabolic changes following a 1-year diet and exercise intervention in patients with type 2 diabetes.

ABSTRACT:

Objective

To characterize the relationships among long-term improvements in peripheral insulin sensitivity (glucose disposal rate [GDR]), fasting glucose, and free fatty acids (FFAs) and concomitant changes in weight and adipose tissue mass and distribution induced by lifestyle intervention in obese individuals with type 2 diabetes.

Research design and methods

We measured GDR, fasting glucose, and FFAs during a euglycemic clamp and adipose tissue mass and distribution, organ fat, and adipocyte size by dual-energy X-ray absorptiometry, CT scan, and adipose tissue biopsy in 26 men and 32 women in the Look-AHEAD trial before and after 1 year of diet and exercise aimed at weight loss.

Results

Weight and fasting glucose decreased significantly (P < 0.0001) and significantl

SUBMITTER: Albu JB 

PROVIDER: S-EPMC2828653 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature