Transient genotype-by-environment interactions following environmental shock provide a source of expression variation for essential genes.

ABSTRACT: Understanding complex genotype-by-environment interactions (GEIs) is crucial for understanding phenotypic variation. An important factor often overlooked in GEI studies is time. We measured the contribution of GEIs to expression variation in four nonlaboratory Saccharomyces cerevisiae strains responding dynamically to a 25 degrees -37 degrees heat shock. GEI was a major force explaining expression variation, affecting 55% of the genes analyzed. Importantly, almost half of these expression patterns showed GEI influence only during the transition between environments, but not in acclimated cells. This class reveals a genotype-by-environment-by-time interaction that affected expression of a large fraction of yeast genes. Strikingly, although transcripts subject to persistent GEI effects were

SUBMITTER: Eng KH 

PROVIDER: S-EPMC2828734 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature