Ontology highlight
ABSTRACT:
SUBMITTER: Li W
PROVIDER: S-EPMC2828953 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Cell 20100201 4
Current models imply that the FERM domain protein Merlin, encoded by the tumor suppressor NF2, inhibits mitogenic signaling at or near the plasma membrane. Here, we show that the closed, growth-inhibitory form of Merlin accumulates in the nucleus, binds to the E3 ubiquitin ligase CRL4(DCAF1), and suppresses its activity. Depletion of DCAF1 blocks the promitogenic effect of inactivation of Merlin. Conversely, enforced expression of a Merlin-insensitive mutant of DCAF1 counteracts the antimitogeni ...[more]