Computational complementation: a modelling approach to study signalling mechanisms during legume autoregulation of nodulation.

ABSTRACT: Autoregulation of nodulation (AON) is a long-distance signalling regulatory system maintaining the balance of symbiotic nodulation in legume plants. However, the intricacy of internal signalling and absence of flux and biochemical data, are a bottleneck for investigation of AON. To address this, a new computational modelling approach called "Computational Complementation" has been developed. The main idea is to use functional-structural modelling to complement the deficiency of an empirical model of a loss-of-function (non-AON) mutant with hypothetical AON mechanisms. If computational complementation demonstrates a phenotype similar to the wild-type plant, the signalling hypothesis would be suggested as "reasonable". Our initial case for application of this approach was to test whether or

SUBMITTER: Han L 

PROVIDER: S-EPMC2829028 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature