Long noncoding RNAs in neuronal-glial fate specification and oligodendrocyte lineage maturation.

ABSTRACT:

Background

Long non-protein-coding RNAs (ncRNAs) are emerging as important regulators of cellular differentiation and are widely expressed in the brain.

Results

Here we show that many long ncRNAs exhibit dynamic expression patterns during neuronal and oligodendrocyte (OL) lineage specification, neuronal-glial fate transitions, and progressive stages of OL lineage elaboration including myelination. Consideration of the genomic context of these dynamically regulated ncRNAs showed they were part of complex transcriptional loci that encompass key neural developmental protein-coding genes, with which they exhibit concordant expression profiles as indicated by both microarray and in situ hybridization analyses. These included ncRNAs associated with differentiation-specific nuclear

SUBMITTER: Mercer TR 

PROVIDER: S-EPMC2829031 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature