Structural diversity and evolution of the N-terminal isoform-specific region of ecdysone receptor-A and -B1 isoforms in insects.

ABSTRACT:

Background

The ecdysone receptor (EcR) regulates various cellular responses to ecdysteroids during insect development. Insects have multiple EcR isoforms with different N-terminal A/B domains that contain the isoform-specific activation function (AF)-1 region. Although distinct physiologic functions of the EcR isoforms have been characterized in higher holometabolous insects, they remain unclear in basal direct-developing insects, in which only A isoform has been identified. To examine the structural basis of the EcR isoform-specific AF-1 regions, we performed a comprehensive structural comparison of the isoform-specific region of the EcR-A and -B1 isoforms in insects.

Results

The EcR isoforms were newly identified in 51 species of insects and non-insect arthropods, includin

SUBMITTER: Watanabe T 

PROVIDER: S-EPMC2829036 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature