Common variants in SLC17A3 gene affect intra-personal variation in serum uric acid levels in longitudinal time series.

ABSTRACT:

Aim

To investigate whether intra-personal variation in serum uric acid concentration is influenced by genes that were described to be associated with serum uric acid levels in cross-sectional studies.

Methods

The study included 92 participants from the isolated community of the Croatian island of Vis. For each participant, two uric acid concentration measurements were available, one from 2002 and one from 2003. Changes in uric acid concentration were correlated with a set of 8 genes known to affect it: PDZK1, GCKR, SLC2A9, ABCG2, LRRC16A, SLC17A3, SLC16A9, and SLC22A12.

Results

Thirteen participants (14%) had uric acid concentration change greater than 130 micromol/L. Greater variability of uric acid concentration was recorded in women (coefficient of variation 49% vs

SUBMITTER: Polasek O 

PROVIDER: S-EPMC2829186 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature