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A beta-carboline alkaloid from the Papua New Guinea marine sponge hyrtios reticulatus.

ABSTRACT: A new 1-imidazoyl-3-carboxy-6-hydroxy-beta-carboline alkaloid, named hyrtiocarboline (1), was isolated from a Papua New Guinea marine sponge, Hyrtios reticulatus. The structure was elucidated from spectroscopic data, including (1)H-(15)N HMBC NMR experiments, which provided complementary (15)N chemical shift information in support of the structure. This compound showed selective antiproliferative activity against H522-T1 non-small cell lung, MDA-MB-435 melanoma, and U937 lymphoma cancer cell lines.

SUBMITTER: Inman WD 

PROVIDER: S-EPMC2829331 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature

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A beta-carboline alkaloid from the Papua New Guinea marine sponge hyrtios reticulatus.

Inman Wayne D WD   Bray Walter M WM   Gassner Nadine C NC   Lokey R Scott RS   Tenney Karen K   Shen Young Yongchun YY   Tendyke Karen K   Suh Ted T   Crews Phillip P  

Journal of natural products 20100201 2

A new 1-imidazoyl-3-carboxy-6-hydroxy-beta-carboline alkaloid, named hyrtiocarboline (1), was isolated from a Papua New Guinea marine sponge, Hyrtios reticulatus. The structure was elucidated from spectroscopic data, including (1)H-(15)N HMBC NMR experiments, which provided complementary (15)N chemical shift information in support of the structure. This compound showed selective antiproliferative activity against H522-T1 non-small cell lung, MDA-MB-435 melanoma, and U937 lymphoma cancer cell lin  ...[more]

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