Towards a genome-scale kinetic model of cellular metabolism.

ABSTRACT:

Background

Advances in bioinformatic techniques and analyses have led to the availability of genome-scale metabolic reconstructions. The size and complexity of such networks often means that their potential behaviour can only be analysed with constraint-based methods. Whilst requiring minimal experimental data, such methods are unable to give insight into cellular substrate concentrations. Instead, the long-term goal of systems biology is to use kinetic modelling to characterize fully the mechanics of each enzymatic reaction, and to combine such knowledge to predict system behaviour.

Results

We describe a method for building a parameterized genome-scale kinetic model of a metabolic network. Simplified linlog kinetics are used and the parameters are extracted from a kinetic m

SUBMITTER: Smallbone K 

PROVIDER: S-EPMC2829494 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature