A simple algebraic cancer equation: calculating how cancers may arise with normal mutation rates.

ABSTRACT:

Background

The purpose of this article is to present a relatively easy to understand cancer model where transformation occurs when the first cell, among many at risk within a colon, accumulates a set of driver mutations. The analysis of this model yields a simple algebraic equation, which takes as inputs the number of stem cells, mutation and division rates, and the number of driver mutations, and makes predictions about cancer epidemiology.

Methods

The equation [p = 1 - (1 - (1 - (1 - u)d)k)Nm ] calculates the probability of cancer (p) and contains five parameters: the number of divisions (d), the number of stem cells (N x m), the number of critical rate-limiting pathway driver mutations (k), and the mutation rate (u). In this model progression to cancer "starts" at concept

SUBMITTER: Calabrese P 

PROVIDER: S-EPMC2829925 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature