Using transcriptomics to identify and validate novel biomarkers of human skeletal muscle cancer cachexia.

ABSTRACT:

Background

Cancer cachexia is a multi-organ tissue wasting syndrome that contributes to morbidity and mortality in many cancer patients. Skeletal muscle loss represents an established key feature yet there is no molecular understanding of the disease process. In fact, the postulated molecular regulators of cancer cachexia originate largely from pre-clinical models and it is unclear how these translate to the clinical environment.

Methods

Rectus abdominis muscle biopsies were obtained from 65 upper gastrointestinal (UGI) cancer patients during open surgery and RNA profiling was performed on a subset of this cohort (n = 21) using the Affymetrix U133+2 platform. Quantitative analysis revealed a gene signature, which underwent technical validation and independent confirmation in

SUBMITTER: Stephens NA 

PROVIDER: S-EPMC2829926 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature