Latent common genetic components of obesity traits.

ABSTRACT:

Background

Obesity is rapidly becoming a global epidemic. Unlike many complex human diseases, obesity is defined not just by a single trait or phenotype, but jointly by measures of anthropometry and metabolic status.

Methods

We applied maximum likelihood factor analysis to identify common latent factors underlying observed covariance in multiple obesity-related measures. Both the genetic components and the mode of inheritance of the common factors were evaluated. A total of 1775 participants from 590 families for whom measures on obesity-related traits were available were included in this study.

Results

The average age of participants was 37 years, 39% of the participants were obese (body mass index >or= 30.0 kg/m(2)) and 26% were overweight (body mass index 25.0-29.9

SUBMITTER: Tayo BO 

PROVIDER: S-EPMC2830146 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature